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GVT CML ALL AML MDS NHL HD MM AA Fanconi PNH SLE HLA HLA 1998 HLA 1998 30% HLA- HLA- GVHD HLA- HLA-˧ 10-20ml/kg 2-3108/kg CD34+2106/kg CFU-GM2105/kg CD34+CFU-GM 24 ABO ABO ABO ABO : G-CSF:10g/kg/d G-CSF 4-5 >6-8108/kg CD34+>2106/kg CFU-GM>2105/kg : +G-CSF CD34+ CD20 4-HC

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C 1/min)-80 -196 ] ABORh HLA- RFLP PCR (VOD) GVHD aGVHD cGVHD total environment protectionTEP BMT LAFR CMV B CMV CMV CMV PCR CMV-DNA CMV-PP65 (CY) mesna 1 : 2 : 2/5

3 : 4 : : VOD ا 4-53% VOD ALT BMT N- GVHD HLA 30%-60% HLA :40%-90% aGVHD 50% 60%-80% cGVHD 100 GVHD aGVHD 100 GVHD cGVHD aGVHD HLA :CsA+MTX GVHD :MMF, FK-506, ATG T T,:CD34+ T,: T, CD8+ aGVHD CsA MMF ATG CD3 FK-506 cGVHD cGVHD aGVHD, aGVHD CsA , CTX cGVHD cGVHD, cGVHD MMF cGVHD , cGVHD 28 >0.5109/L 0.5109 /L HLA

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T O CMVEBVGVHD GM-CSFG-CSF Bone Marrow Donors Worldwide (BMDW) HLA HLA CD34+ T NK y GVL

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?GVHD 50% ----- ? GVHD GVL ? ?
GVHD HLA1-3 HLA 4/5

HLA GVL GVHD T DLI CR GVL CMVHIVEBV T T T mHAg) (PR3 WT-1) mHAg Riddell 38 mHAg mHAg CD8+mHAg T T mHAg Mutis mHAgs T mHAgs T T CR GVHD mHAg T --- 3PR3 PR3 PR3 CML PR3 CD8+CTL PR3 CD8+CTL CML - ---Wilms WT-1 Wilms WT1 AMLCMLALLWT1 WT-1 CD34+ 10 100 WT-1 CD8+CTLs CD34+ CD34+ NK GVL T GVL y GVHD ] T GVHD Ruggeri HLA NK GVL NK GVL NK KIR KIRkiller immunoglobulin C like receptor) KIR HLA- KIR NK GVL NK GVL -- NK GVL GVHD AML 5 NK 60% NK 5% KIR ALL GVL

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