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(SCT) , 1(ASCT) 2 (Allo-SCT) 3(SCT)

1(BMT) 2(PBSCT) 3(NCSCT) 4(NLSCT)



(BMT) , , , ,

, (ABMT) (Allo-BMT) (SBMT)

()(ABMT) ҵ ,/ , ,, (GVHD),

ABMT: , ,

, 72 , -196

( )BMT, ,, GVHD, ,

(SBMT) , ,, GVHD, , Allo-BMT,

(Allo-BMT) (MHC) ,, (HLA) GVHD,ABMT SBMT

: (): (1)250 (2),Ǧ CR1,CR2 ( )

(3) (4)5.0 (forced vital capatity)60% (DLCO)50% (5)110 mol/L(2mg/dl) 18 mol/L(2mg/dl

: HLA , ABO

HLA ,HLA ,

(Allo-BMT) (SBMT) : 1.HLA, PCRHLA-ABCDR, HLA

2.: ݌ -(GM-CFU) ,

(), 4 Q600 800

3. , ,,

,X

, ,2030 ,, ,,

4. ,

(1): :(CTX) : (CTX+TBI (2): CTX+TBI :CTX++TBI

,Q ,/ /, ,, 1015ml,10 15ml/Kg(6001000ml)

1SBMT3.0-5.0107/Kg 2Allo-BMT2.0-6.0108/Kg 400ml, ,, K

2 1718, (0.2010.307mm) 1640 ,1520

3 ,, , , (1mg 100u)

Allo-BMT 1 HLAIIIIII

2 GVHD 324

ABMT5.030.0109 0.55.0108/kg CFUC1.04.0104/kg

0.2010.307mm 15-20U 4C3648 10 b 196

y ١

ABMT CTXTBI FTBI

ABMT 1.0109/L1621 50109/L1421 >0.510 9/l21



1APBSCT 2 Allo-PBSCT)

110PBSCT 1

2 1 2 25100

PBSCT Allo-PBSCTGMCSF GCSF

1 123 1.0-2.0)109/L G-CSF5.510.0?50109/L 2CD34?1 0.2?0.1

2 Fenwall CS300034COBE SPECTRA12

] PBSCT CD342.5106/kg CD34

50ml 20DMSO RDMI1640DMSO 10 100ml

1/min45 510/min 8090 196

4042 3min DMSO RPMI1640 400600ml1

PMN PMN? 0.5 109/L11 34

PMN ? 50.0109/L13



70ܧ 80

(1) (2) ACD CPD

42240 103ml1.02.010 9/l(MNC)1.0109,CD34 1.0107 50

(1)20 DMSO5 h2

T GVHD

1ANC ?5.0109/L 2224 2?5.0109/L 48 54



1958Uphoff 36ʧ 2 T. GVHD

ާ 100200 20ml10ml 4

1T

15mm10ml 4 1500/min20min CFUGM7489

11





,
IPNAll0 BMTGVHD 40

]HE



CGL

(1) (2)T HLAGVHD BMT

(3) (4) (5)


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