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(HSCT) 宏完

快 1958 Mathe 1968 Gatti 迄70(HLA) 1977100 HLA 13i紫迄 曳50%70% 1990抄1964 1981 75%70 1988 Gluckman HLA 1989 G-CSF 1994 20 完 宏尿抉 (IBMTR尿 龑抄 抉 芍抄10 戒 30 90抄1402000 50000 1000 (1) (2) 抗

(3) 獺妊 (4) 汛 (1) (2)/// / (3) HLA // HLA (4) (5) ( ) HLA 誸 忍 HLA (HLA)龑() HLA 曳 HLA 技 ABCDRB1 HLA HLA 1/41/2 1/4 HLA HLA HLA GVHD ()HLA HLA 抖140 HLA 60% HLA HLA 4/6 . 1.(cGVHD) cGVHD 36-12 aGVHD 汛 aGVHD 3 cGVHDcGVHD aGVHDcGVHD (Sjgren ) 汕cGVHD 戒cGVHD 竹 cGVHD cGVHD cGVHD cGVHD 阱CsA cGVHD 齋 CD20 CD25 cGVHD 完芍 cGVHD cGVHD 完 cGVHD cGVHD

2.汕 3-12 cGVHD 抄曳(TBI) MTX GVHD CT 完 50%牝 技糸 3. (Posttransplant lymphoproliferative disorders PTLD)(MDS)PTLD PTLD 曳(HLA ) PTLD 1%5%曳( T HLA ) 10%30%(ABMT) 1%? 2% 戒 PTLD 曳(1) T ;(2)HLA ( );(3);(4)(5)1 PTLD 曳 GVHDPTLD B T EBV PTLD (PCR) EBV-DNA PTLD 完 PTLD (1) PTLD (2) 有有完 (3) B , CD20完83%(4) EBV PTLD EBV T (cytotoxic T cells, CTLs) EBV CTLs EBV B (5)( CHOP ProMACE-CytaBOM ) 4. TBI 抄 TBI 26 10%20%‾ 5. 完20%-30%(>95%) 辰抄妊, 忘 G-CSF (IL-2) 孝 快 宏快宏 , 6. TBI 抗完 TBI 汍 TBI妊 cGVHD 技曳芍 7. Cy 妊TBI 汍 TBI TBI 妊( TBI )90%,

TBI TBI , , : ㊣鑇 : ()12 00030 min 屁100 迄:1 d 迄芍 100(LAFR)LAFR 鳺0.05%1 /0.8%曲 12 000 30 min 芍30 min 芍 妊 1曲1%迄0.5%2曲75% 3曲75% ] 抗 覤 嚮


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