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忍/ / 1957 Thomas 快 快 1988 GlucKmen 汕 Fanconi 車 1964 1981 抄1996 1998 扶 完 180 70% 30%-50% Fred Hutchinson 抉 CR1 AML 3 乃FS 50 3 DFS 18%-27% APL APL 完 完 a. Barrett ALL CR 5 29 9%DFS 42 9% CR2 5 52 8%DSF 26 6%曳 ALL CR1 曳 ALL 曳 b. ALL 完 AML AML 完C.GVHD : GVHD 扭 ; GVHD .d., GVHD ,DFS . 2.(CML)扭 CML CML 朵完DFS 50%-90% DFS 10%-30%完完宏 DFS 志 dfs 快 宏曳 Burkitts

(MDS)扭 MDS 抄鑴 MDS-RAEB, MDS-RAEBT. 5MM MM CR 43% 宏 4 DFS 50% 3 DFS 69; MM 6.(CLL) 50% CR CLL SAA孝SAA ,DFS 30 SAA 完 抄 妊完 DFS 迄 GVHD DFS 完 Wiskott-Aldrich Chediak-Higashi HLA 75%-90% T (222 )(CY) (BU) HLA DFS 75%汛污完 宏抖 百 HLA HLA HLA HLA-ABDR HLA GVHD HLA HLA 竹 HLA-ABDR 孝 HLA 完 HLA HLA 250 ^孝抄妊CML UBMT 抉 Gluckman Fanconi

GVHD II GVHD 4%,HLA GVHD HLA GVHD HLA GVHD Robinstein II-IV GVHD Robinstein GVHD HLA 竹 完忱 HLA HLA HLA"" HLA 完 宏 HLA ^ :忌 T ? T GVHD , ,,CMV . T 汛CML T T MDS T 宏 T 扭 HLA 竹 T 鱱竹 " " MHC,""(HLA)HLAI II 妊 MHC 竹竹 邦 HLA HLAI HLA-ABC 竹II HLA-DRDPDQ 竹HLA 迄 HLA HLA 迄扭 HLA 抄妊 HLA HLA CML 忍 SAA 竹 HLA 竹HLA 竹 GVHD DFS HLA HLA 竹 GVHD DFS 妊 忱快 愐污"" (TBI) TBI 志 TBI TBI 蘟

TBI BU+CY ㊣

BU-CY BU CY 1mg/(kg.Q6h)X4d (9 6 4 )

500mg/Kg.Q6h)X4g/d (5 2 )

___________________________________________________________________________ BU+CY , VOD , TvschKa.P.J 快 CY 4 2 , BU+CY2 ,完, 抉 BU+CY2 我, BU 4 3 , Ara-CCCUNHU 完 TBI 竹竹抗 1.0x108/kg 3.0 X 108/kg宏妊 煠忪鉸Thomas 愐 ""媕 曲 2.5-3 : 百污 ABO 梖 ABO ABO 快 ABO A B O 帨ABO 妊快 ABO O A B 帨 ABO ABO 妊 A B B A ABO 快毰忪鉸 妊妊汎汎 , 快孝 rhH-CSF 310ug/kg/ 迆^ GM-CSF IL-3 G-CSF 抗 103/Kg孝 妊 妊 50X109/L 我抗ABO

曳 CML 汐朵 曳 我孝 CML HLA 快 CML 完 扶 UBMT CR 孝MDS HLA Sweenberg 辰宏 CMV ,汕 ( 1).,,我 曳 PBSCT


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